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KMID : 0191120130280091340
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Journal of Korean Medical Science
2013 Volume.28 No. 9 p.1340 ~ p.1344
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The Clinical Measures Associated with C-peptide Decline in Patients with Type 1 Diabetes over 15 Years
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Lee Tae-Ho
Kwon Ah-Reum
Kim Ye-Jin
Chae Hyun-Wook
Kim Ho-Seong
Kim Duk-Hee
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Abstract
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This study was done to characterize the natural course of C-peptide levels in patients with type 1 diabetes and identify distinguishing characters among patients with lower rates of C-peptide decline. A sample of 95 children with type 1 diabetes was analyzed to retrospectively track serum levels of C-peptide, HbA1c, weight, BMI, and diabetic complications for the 15 yr after diagnosis. The clinical characteristics were compared between the patients with low and high C-peptide levels, respectively. The average C-peptide level among all patients was significantly reduced five years after diagnosis (P < 0.001). The incidence of diabetic ketoacidosis was significantly lower among the patients with high levels of C-peptide (P = 0.038). The body weight and BMI standard deviation scores (SDS) 15 yr after diagnosis were significantly higher among the patients with low C-peptide levels (weight SDS, P = 0.012; BMI SDS, P = 0.044). In conclusion, C-peptide level was significantly decreased after 5 yr from diagnosis. Type 1 diabetes patients whose beta-cell functions were preserved might have low incidence of diabetic ketoacidosis. The declines of C-peptide level after diagnosis in type 1 diabetes may be associated with changes of body weight and BMI.
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KEYWORD
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Diabetes Mellitus, Type 1, C-Peptide, Body Weight, Body Mass Index, Diabetic Ketoacidosis
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